Primal Health Databank: Study
| Entry No: | 0652 |
| Title: | Glucose regulation in young adults with very low birth weight |
| Author(s): | Hovi P, Andersson S, Eriksson JG, Jarvenpaa AL, Strang-Karlsson S, Makitie O, Kajantie E |
| Reference: | N Engl J Med. 2007 May 17;356(20):2053-63 |
| Place of Study: | Finland |
| Abstract: | The authors assessed glucose tolerance and insulin sensitivity and measured serum lipid levels and blood pressure in young adults with very low birth weight. They performed a standard 75-g oral glucose-tolerance test, measuring insulin and glucose concentrations at baseline and at 120 minutes in 163 young adults (age range, 18 to 27 years) with very low birth weight and in 169 subjects who had been born at term and were not small for gestational age. The two groups were similar with regard to age, sex, and birth hospital. They measured blood pressure and serum lipid levels, and in 150 very-low-birth-weight subjects and 136 subjects born at term, they also measured body composition by means of dual-energy x-ray absorptiometry. As compared with the subjects born at term, the very-low-birth-weight subjects had a 6.7% increase in the 2-hour glucose concentration (95% confidence interval [CI], 0.8 to 12.9), a 16.7% increase in the fasting insulin concentration (95% CI, 4.6 to 30.2), a 40.0% increase in the 2-hour insulin concentration (95% CI, 17.5 to 66.8), an 18.9% increase in the insulin-resistance index determined by homeostatic model assessment (95% CI, 5.7 to 33.7), and an increase of 4.8 mm Hg in systolic blood pressure (95% CI, 2.1 to 7.4). Adjustment for the lower lean body mass in the very-low-birth-weight subjects did not attenuate these relationships. The authors conclude that young adults with a very low birth weight have higher indexes of insulin resistance and glucose intolerance and higher blood pressure than those born at term.
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| Keyword(s): | birth weight, diabetes type 1, diabetes type 2, insulin resistance, low birth weight |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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