Primal Health Databank: Study
| Entry No: | 0648 |
| Title: | Association between thimerosal-containing vaccine and autism |
| Author(s): | Hviid A, Stellfeld M, Wohlfahrt J, Melbye M, Joner G; Norwegian Childhood Diabetes Study Group, Stuver SO, Hsieh C |
| Reference: | JAMA. 2003 Oct 1;290(13):1763-6 |
| Place of Study: | Denmark |
| Abstract: | The objective of this study was to determine whether vaccination with a thimerosal-containing vaccine is associated with development of autism. This is a population-based cohort study of all children born in Denmark from January 1, 1990, until December 31, 1996 (N = 467 450) comparing children vaccinated with a thimerosal-containing vaccine with children vaccinated with a thimerosal-free formulation of the same vaccine. During 2 986 654 person-years, the authors identified 440 autism cases and 787 cases of other autistic-spectrum disorders. The risk of autism and other autistic-spectrum disorders did not differ significantly between children vaccinated with thimerosal-containing vaccine and children vaccinated with thimerosal-free vaccine (RR, 0.85 [95% confidence interval [CI], 0.60-1.20] for autism; RR, 1.12 [95% CI, 0.88-1.43] for other autistic-spectrum disorders). Furthermore, we found no evidence of a dose-response association (increase in RR per 25 microg of ethylmercury, 0.98 [95% CI, 0.90-1.06] for autism and 1.03 [95% CI, 0.98-1.09] for other autistic-spectrum disorders). The results do not support a causal relationship between childhood vaccination with thimerosal-containing vaccines and development of autistic-spectrum disorders. |
| Keyword(s): | autism, autistic spectrum disorder, labour induction, mercury, pre-eclampsia, preeclampsia, Rhesus-immunization, vaccination, vaccination |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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