Primal Health Databank: Study
| Entry No: | 0646 |
| Title: | Maternal and paternal age and risk of autism spectrum disorders |
| Author(s): | Croen LA, Najjar DV, Fireman B, Grether JK, Joner G; Norwegian Childhood Diabetes Study Group, Stuver SO, Hsieh C |
| Reference: | Arch Pediatr Adolesc Med. 2007 Apr;161(4):334-40 |
| Place of Study: | USA |
| Abstract: | 1: . Links
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Author Affiliations: Division of Research, Kaiser Permanente Medical Care Program, Oakland.
All singleton children born at Kaiser Permanenty hospitals (KP) from January 1, 1995, to December 31, 1999, were included in the study. The authors identified 593 children who had ASD diagnoses (International Classification of Diseases, Ninth Revision, Clinical Modification, code 299.0 or 299.8) recorded 2 or more times in KP outpatient databases before May 2005. These children were compared with all 132 251 remaining singleton KP births. Risk of ASDs increased significantly with each 10-year increase in maternal age (adjusted RR, 1.31; 95% confidence interval [CI], 1.07-1.62) and paternal age (RR, 1.28; 95% CI, 1.09-1.51). Adjusted RRs for both maternal and paternal age were elevated for children with autistic disorder (maternal age: RR, 1.18; 95% CI, 0.87-1.60; paternal age: RR, 1.34; 95% CI, 1.06-1.69) and children with Asperger disorder or pervasive developmental disorder not otherwise specified (maternal age: RR, 1.45; 95% CI, 1.09-1.93; paternal age: RR, 1.24; 95% CI, 0.99-1.55). Associations with parental age were somewhat stronger for girls than for boys, although sex differences were not statistically significant. |
| Keyword(s): | autism, autistic spectrum disorder, labour induction, maternal age, paternal age, pre-eclampsia, preeclampsia, Rhesus-immunization, vaccination |
| Discussion: | Pre- and perinatal environmental factors were not taken into account in this study. |
| See Also: | No related entries mentioned for this entry |
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