Primal Health Databank: Study
| Entry No: | 0643 |
| Title: | Prediction from low birth weight to female adolescent depression: a test of competing hypotheses |
| Author(s): | Costello EJ, Worthman C, Erkanli A, Angold A |
| Reference: | Arch Gen Psychiatry. 2007 Mar;64(3):338-44 |
| Place of Study: | USA |
| Abstract: | A representative population-based sample from an 11-county area in western North Carolina was assessed annually for psychiatric disorders between the ages of 9 and 16 years. The authors tested the prediction from low birth weight (LBW) and depression in models that included LBW only, LBW plus other prenatal and perinatal adversities, LBW plus significant perinatal and childhood adversities, and LBW plus significant perinatal and childhood adversities and adolescent correlates. There were 1420 participants, of whom 49% were female. The cumulative prevalence of depression among adolescent girls with LBW was 38.1% (95% confidence interval [CI], 16.3%-66.0%) compared with 8.4% (95% CI, 5.2%-13.3%) among adolescent girls with normal birth weight. Rates among children and adolescent boys did not exceed 4.9%. In adolescence, there was a significant interaction between LBW and sex (odds ratio, 0.2 [95% CI, 0.1-0.5]; P<.001). Low birth weight predicted female adolescent depression after controlling for other perinatal, childhood, and adolescent adversities. Girls with LBW and normal birth weight with no adversities had no adolescent depression, but each additional adversity increased the risk in girls with LBW more than in girls with normal birth weight. Low birth weight did not predict other psychiatric disorders in either sex. CONCLUSIONS: Low birth weight predicts depression in adolescent girls but not boys. |
| Keyword(s): | birthweight, depression, low birth weight |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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