Primal Health Databank: Study
| Entry No: | 0605 |
| Title: | Low Maternal Vitamin E Intake during Pregnancy Is Associated with Asthma in 5-Year-Old |
| Author(s): | Devereux G, Turner SW, Craig LC, McNeill G, Martindale S, Harbour PJ, Helms PJ, Seaton A |
| Reference: | Am J Respir Crit Care Med. 2006 Sep 1;174(5):499-507. |
| Place of Study: | UK |
| Abstract: | This is a longitudinal cohort study of 1,861 children born to women recruited during pregnancy and followed up at 5 yr. Maternal nutrient status was assessed by a food frequency questionnaire and plasma levels. Respiratory and food frequency questionnaires were completed at 5 yr and children were invited for measurement of spirometry and skin-prick testing. Symptom and food frequency questionnaire data were available for 1,253 and 1,120 children, respectively; 700 children were skin prick tested, and FEV(1) was measured in 478 and exhaled nitric oxide in 167 children. In 5-yr-old children, maternal vitamin E intake during pregnancy was negatively associated with wheeze in previous year (odds ratio per intake quintile, 0.82; 95% confidence interval, 0.71-0.95), asthma ever (0.84, 0.72-0.98), asthma and wheeze in previous year (0.79, 0.65-0.95), and persistent wheezing (0.77, 0.63-0.93). Maternal plasma alpha-tocopherol during pregnancy was positively associated with post-bronchodilator FEV(1) at 5 yr, with a 7-ml (95% confidence interval, 0-14; p = 0.04) increase in FEV(1) per mug/ml alpha-tocopherol. Maternal zinc intake during pregnancy was negatively associated with asthma ever (0.83, 0.71-0.78) and active asthma (0.72, 0.59-0.89). There were no associations between children's nutrient intake and respiratory outcomes. Conclusion: Maternal intake of foods containing vitamin E and zinc during pregnancy is associated with differences in the risks of developing childhood wheeze and asthma.
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| Keyword(s): | asthma, vitamin E, zinc |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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