Primal Health Databank: Study
| Entry No: | 0604 |
| Title: | The prenatal use of antibiotics and the development of allergic disease in one year old infants. A preliminary study |
| Author(s): | Jedrychowski W, Galas A, Whyatt R, Perera F |
| Reference: | Int J Occup Med Environ Health. 2006;19(1):70-6 |
| Place of Study: | Poland |
| Abstract: | Nonsmoking women, aged 18-35 years, were enrolled in 2000/2001 from prenatal clinics during the second or third trimester of pregnancy. After delivery, newborns were followed-up every three months over one year and trained interviewers conducted a standardized interview with mothers on infants' health at each visit held every three-month. In total, 102 infants were followed over a one-year period and questionnaires on the use of various medications during pregnancy and potential risk factors for allergy and asthma were completed. Relative risk for persistent wheezing (9+ days over the follow-up) adjusted for potential confounders was significantly associated with the duration of antibiotic therapy; however, it was significant only if the antibiotic treatment took place in the second and the third trimester. The adjusted relative risk was increasing by 14% with each day of using antibiotics compared with the reference group (RR = 1.14; 95% CI: 1.01-1.27). When usage of antibiotics was regarded as a dichotomous variable in the logistic model (cut-off point at 5 days), the estimated adjusted risk for persistent wheezing was 4.42 (95% CI: 1.05-18.8). The risk for hay fever due to exposure to antibiotics was 2.65 (95% CI: 1.03-6.81) and a corresponding estimate for eczema was 2.30 (95% CI: 0.91-5.80). This study suggests that maternal use of antibiotics during pregnancy may prove to be a risk factor for persistent wheezing and development of allergy in early infancy.
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| Keyword(s): | allergic disease, antibiotics, wheezing |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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