Primal Health Databank: Study

Entry No:0596
Title:Perinatal risk factors for cancer of the esophagus and gastric cardia: a nested case-control study
Author(s):Akre O, Forssell L, Kaijser M, Noren-Nilsson I, Lagergren J, Nyren O, Ekbom A
Reference:Cancer Epidemiol Biomarkers Prev. 2006 May;15(5):867-71
Place of Study:Sweden
Abstract: This is a nested case-control study of 67 cases of esophageal adenocarcinoma and 93 cases of cardia adenocarcinoma, whereas 50 cases of squamous cell carcinoma were studied for comparison. Birth records of cases were traced. Three matched controls per case were randomly selected. Perinatal data were extracted from birth records. Long gestational duration was associated with a decreased risk of cardia adenocarcinoma (P(trend) = 0.001) and a nonsignificant decreased risk of esophageal adenocarcinoma (P = 0.07), whereas no such association was found for esophageal squamous cell carcinoma (P = 0.96). Birth weight was not associated with risk of any of the studied cancers. Compared with lower maternal age (
Keyword(s):birth weight, cardia adenocarcinoma, esophageal adenocarcinoma, prematurity, small for gestational age
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