Primal Health Databank: Study
| Entry No: | 0595 |
| Title: | Intergenerational effects of preterm birth and reduced intrauterine growth: a population-based study of Swedish mother-offspring pairs |
| Author(s): | Selling KE, Carstensen J, Finnstrom O, Sydsjo G |
| Reference: | BJOG. 2006 Apr;113(4):430-40 |
| Place of Study: | Sweden |
| Abstract: | The objective of this study was to estimate the intergenerational effects of preterm birth and reduced intrauterine growth. This is a population-based cohort study involving a population of children born before 2001 to 38 720 women born in 1973-75. The relationships between the mother's and the child's birth characteristics were estimated using logistic regression analysis. Adjustments were made for smoking habits, body mass index (BMI), and current and childhood socio-economic conditions. Analyses were performed on all mother-offspring pairs and on the pairs for which information on neither of the included background variables was missing (n= 24 520). Mothers who themselves had been born preterm were not significantly more likely to deliver their own children preterm, compared with those who had been born at term (adjusted OR 1.24, 95% CI 0.95-1.62). Also, preterm birth in the mothers did not influence the occurrence of small for gestational newborns. However, the odds ratio for giving birth to small for dates and preterm children, respectively, was higher among mothers born small for gestational age (OR 2.68, 95% CI 2.11-3.41 and OR 1.30, 95% CI 1.05-1.61). The present study showed evidence of intergenerational effects of reduced intrauterine growth even when socio-economic factors as well as BMI and smoking were adjusted for. There was, however, no consistent intergenerational effect of preterm birth.
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| Keyword(s): | intergenerational studies, prematurity, small for gestational age |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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