Primal Health Databank: Study
| Entry No: | 0594 |
| Title: | Risk of childhood asthma and allergic rhinitis in relation to pregnancy complications |
| Author(s): | Nafstad P, Magnus P, Jaakkola JJ |
| Reference: | J Allergy Clin Immunol. 2000 Nov;106(5):867-73 |
| Place of Study: | Norway |
| Abstract: | The authors sought to elaborate the relations between the occurrence of pregnancy complications and other pregnancy-related conditions and the risk of bronchial obstruction during the first 2 years of life and the occurrence of asthma and allergic rhinitis by the age of 4 years. Pregnancy complications were considered both as predictors of the health outcomes and as possible effects caused by other prenatal factors. A population-based, 4-year, cohort study was carried out involving 2531 children born in Oslo, Norway. The authors collected information on maternally related (hyperemesis, hypertension, and preeclampsia) and uterus-related complications in pregnancy (antepartum hemorrhage, preterm contractions, insufficient placenta, and restricted growth of the uterus) and the child's health and environmental exposures at birth and at 6, 12, 18, and 24 months and 4 years of age. The outcomes of interest were bronchial obstruction during the first 2 years and asthma and allergic rhinitis at the age of 4 years. In a logistic regression analysis adjusting for potential confounders, uterus-related, but not other pregnancy-related, complications increased the risk of bronchial obstruction (odds ratio [OR], 2.1; 95% confidence interval [CI], 1.3-3.4), asthma (OR, 3.0; 95% CI, 1.8-5.4), and allergic rhinitis (OR, 2.9; 95% CI, 1.6-5.2). These relations were similar in children of atopic and nonatopic parents. |
| Keyword(s): | allergic disease, allergic rhinitis, asthma, atopy |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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