Primal Health Databank: Study
| Entry No: | 0582 |
| Title: | Breastfeeding and risk of schizophrenia in the Copenhagen Perinatal Cohort |
| Author(s): | Sorensen HJ, Mortensen EL, Reinisch JM, Mednick SA |
| Reference: | Acta Psychiatr Scand. 2005 Jul;112(1):26-9 |
| Place of Study: | Denmark |
| Abstract: | The aim was to study whether early weaning from breastfeeding may be associated with increased risk of schizophrenia. The current sample comprises 6841 individuals from the Copenhagen Perinatal Cohort of whom 1671 (24%) had been breastfed for 2 weeks or less (early weaning) and 5170 (76%) had been breastfed longer. Maternal schizophrenia, parental social status, single mother status and gender were included as covariates in a multiple regression analysis of the effect of early weaning on the risk of hospitalization with schizophrenia. The sample comprised 93 cases of schizophrenia (1.4%). Maternal schizophrenia was the strongest risk factor and a significant association between single mother status and elevated offspring risk of schizophrenia was also observed. Early weaning was significantly related to later schizophrenia in both unadjusted and adjusted analyses (adjusted odds ratio 1.73 with 95% CI: 1.13-2.67). No or <2 weeks of breastfeeding was associated with elevated risk of schizophrenia. |
| Keyword(s): | breastfeeding, schizophrenia |
| Discussion: | When comparing this study with others (see entries 306 and 439)it appears that the protective effect of breastfeeding appears only if the cutoff for early weaning is 2 weeks instead of 1 month. It is more and more obvious that schizophrenia may be presented as the long term consequence of very early developmental defects. |
| See Also: | No related entries mentioned for this entry |
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