Primal Health Databank: Study
| Entry No: | 0577 |
| Title: | Maternal vitamin D status during pregnancy and childhood bone mass at age 9 years: a longitudinal study |
| Author(s): | Javaid MK, Crozier SR, Harvey NC, et al. |
| Reference: | The Lancet 2006; 367:36-43 |
| Place of Study: | UK |
| Abstract: | In a longitudinal study, the authors studied 198 children born in 1991–92 in a hospital in Southampton, UK; the body build, nutrition, and vitamin D status of their mothers had been characterised during pregnancy. The children were followed up at age 9 years to relate these maternal characteristics to their body size and bone mass.
49 (31%) mothers had insufficient and 28 (18%) had deficient circulating concentrations of 25(OH)-vitamin D during late pregnancy. Reduced concentration of 25(OH)-vitamin D in mothers during late pregnancy was associated with reduced whole-body (r=0·21, p=0·0088) and lumbar-spine (r=0·17, p=0·03) bone-mineral content in children at age 9 years. Both the estimated exposure to ultraviolet B radiation during late pregnancy and the maternal use of vitamin D supplements predicted maternal 25(OH)-vitamin D concentration (p<0·0001 and p=0·0110, respectively) and childhood bone mass (p=0·0267). Reduced concentration of umbilical-venous calcium also predicted reduced childhood bone mass (p=0·0286).
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| Keyword(s): | bone density, vitamin D |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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