Primal Health Databank: Study
| Entry No: | 0566 |
| Title: | Association of intrapartum antibiotic exposure and late-onset serious bacterial infections in infants |
| Author(s): | Glasgow TS, Young PC, Wallin J, Kwok C, Stoddard G, Firth S, Samore M, Byington CL |
| Reference: | Pediatrics. 2005 Sep;116(3):696-702 |
| Place of Study: | USA |
| Abstract: | The objectives of this study were to determine whether infants with late-onset serious bacterial infections were more likely than healthy control infants to have been exposed to intrapartum antibiotics and whether there was a greater likelihood of antibiotic resistance in bacteria that were isolated from infants who had a serious bacterial infection and had been exposed to intrapartum antibiotics compared with those who had not. The authors used a case-control design to study the first objective. Cases were previously healthy full-term infants who were hospitalized for late-onset serious bacterial infections between the ages of 7 and 90 days. Control subjects were healthy full-term infants who were known not to have a serious bacterial infection in their first 90 days. Cases and control subjects were matched for hospital of delivery. In the second part of the study, rates of antibiotic resistance of bacteria that were isolated from infected infants were compared for those who had and had not been exposed to intrapartum antibiotics. Ninety case infants and 92 control subjects were studied. Considering all types of intrapartum antibiotics, more case (41%) than control infants (27%) had been exposed to intrapartum antibiotics (adjusted odds ratio [OR]: 1.96; 95% confidence interval [CI]: 1.05-3.66), after controlling for hospital of delivery. The association was stronger when intrapartum antibiotherapy was with broad-spectrum antibiotics (adjusted OR: 4.95; 95% CI: 2.04-11.98), after controlling for hospital of delivery, maternal chorioamnionitis, and breastfeeding. Bacteria that were isolated from infected infants who had been exposed to intrapartum antibiotics were more likely to exhibit ampicillin resistance (adjusted OR: 5.7; 95% CI: 2.3-14.3), after controlling for hospital of delivery, but not to other antibiotics that are commonly used to treat SBI in infants. |
| Keyword(s): | antibiotic resistance, antibiotics, bacterial infections, intrapartum antibiotics |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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