Primal Health Databank: Study

Entry No:0561
Title:The dangerous road of catch-up growth
Author(s):Hales CN, Ozanne SE
Reference:J Physiol. 2003 Feb 15;547(Pt 1):5-10
Place of Study:UK
Abstract: Male rats growth-retarded during fetal life and cross-fostered shortly after birth to normal lactating dams reach normal body and organ weights by weaning but have a reduced longevity. This finding raises the possibility that catch up growth, whilst potentially beneficial in the short term, may be detrimental to long-term survival. Human epidemiological studies may point in the same direction. These findings raise the interesting possibility that the response to fetal stress, be it nutritional or other, may evoke a somewhat restricted and uniform pattern of adaptive response.
Keyword(s):birthweight, catch-up growth, fetal growth, intrauterine growth retardation
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