Primal Health Databank: Study
| Entry No: | 0534 |
| Title: | Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation |
| Author(s): | Elena Zambrano, Paola María Martínez-Samayoa, Claudia Janet Bautista, Martha Deás, Lucía Guillén, Guadalupe Leticia Rodríguez-González, Carolina Guzmán, Fernando Larrea, and Peter Nathanielsz |
| Reference: | J Physiol published April 28, 2005, 10.1113/jphysiol.2005.086462 |
| Place of Study: | USA |
| Abstract: | One of the most interesting and significant features of developmental programming is the evidence from several studies that the adverse consequences of altered intrauterine environments can be passed transgenerationally from mother (F0) to daughter (F1) to second generation offspring (F2). The authors determined whether when F0 female rats are exposed to protein restriction during pregnancy and/or lactation, their F1 female pups deliver F2 offspring with in vivo evidence of altered glucose and insulin metabolism. They fed F0 virgin Wistar rats a normal control 20% casein diet (C) or a protein restricted isocaloric diet (R) containing 10% casein during pregnancy. F1 female R pups weighed less than C at birth. After delivery, mothers received C or R diet during lactation to provide four F1 offspring groups CC (first letter pregnancy diet and second lactation diet), RR, CR, and RC. All F1 female offspring were fed ad libitum with C diet after weaning and during their first pregnancy and lactation. As they grew female offspring (F1) of RR and CR mothers exhibited low body weight and food intake with increased sensitivity to insulin during a glucose tolerance test at 110 days of postnatal life. Male F2 CR offspring showed evidence of insulin resistance. In contrast RC F2 females showed evidence of insulin resistance. Gender differences were also observed in F2 offspring in resting glucose and insulin and insulin:glucose ratios. These gender differences also showed stage of development time window specific differences. The authors conclude that maternal protein restriction adversely impacts glucose and insulin metabolism of male and female F2 offspring in a gender specific and developmental time window specific manner during their mother's (the F1) fetal and neonatal development.
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| Keyword(s): | diabetes, experimental Primal Health research, obesity, second generation |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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