Primal Health Databank: Study
| Entry No: | 0532 |
| Title: | Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula |
| Author(s): | Stettler N, Stallings VA, Troxel AB, Zhao J, Schinnar R, Nelson SE, Ziegler EE, Strom BL |
| Reference: | Circulation. 2005 Apr 19;111(15):1897-903 |
| Place of Study: | USA |
| Abstract: | A cohort of European American formula-fed subjects, measured on 7 occasions during infancy as part of several infant formula studies, were contacted at age 20 to 32 years, when they reported usual adult weight and height. A life-course plot was used to identify critical periods of weight gain associated with adulthood overweight (body mass index > or =25 kg/m2). These associations were tested with logistic regressions. Data were available for 653 subjects (72% of eligible subjects). Approximately 32% of them were overweight adults. The period between birth and age 8 days was identified as potentially critical. After adjustment for important confounding factors, weight gain during the first week of life was associated with adulthood overweight status (OR for each 100-g increase 1.28, 95% CI 1.08 to 1.52), as was weight gain during the first 112 days of life (OR 1.04, 95% CI 1.01 to 1.08). Similar results were obtained after standardization with z scores from a reference population. CONCLUSIONS: In formula-fed infants, weight gain during the first week of life may be a critical determinant for the development of obesity several decades later. These results contribute to the understanding of chronic disease programming and suggest new approaches to obesity prevention |
| Keyword(s): | bottle feeding, infant feeding, obesity |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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