Primal Health Databank: Study
| Entry No: | 0528 |
| Title: | Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders: a case-control study |
| Author(s): | Croen LA, Grether JK, Yoshida CK, Odouli R, Van de Water J, Lloyd DJ, Dean JC |
| Reference: | Arch Pediatr Adolesc Med. 2005 Feb;159(2):151-7 |
| Place of Study: | USA |
| Abstract: | This is a case-control study nested within a cohort of infants born between January 1995 and June 1999. SETTING: Northern California Kaiser Permanente Medical Care Program. PARTICIPANTS: Cases (n = 420) were children with at least 1 diagnosis of an autism spectrum disorder (ASD) recorded in Kaiser Permanente outpatient clinical databases. Controls (n = 2100) were children without an ASD diagnosis who were frequency matched to cases on sex, birth year, and hospital of birth. MAIN OUTCOME MEASURES: Frequencies of maternal immunologic disorders were compared between cases and controls with a chi2 statistic, and relative risks were estimated by crude and adjusted odds ratios and 95% confidence intervals using logistic regression. RESULTS: The final study population included 407 cases and 2095 controls. A similar proportion of case and control mothers had a diagnosis of any autoimmune disease in the 4-year period surrounding pregnancy (10.3% vs 8.2%, P = .15). After adjustment for maternal factors, only 1 autoimmune condition, psoriasis, was significantly associated with ASDs (adjusted odds ratio, 2.7; 95% confidence interval, 1.3-5.8). A greater than 2-fold elevated risk of ASD was observed for maternal asthma and allergy diagnoses recorded during the second trimester of pregnancy. |
| Keyword(s): | allergic disease, asthma, autism, autistic spectrum disorder, autoimmune diseases, labour induction, pre-eclampsia, preeclampsia, Rhesus-immunization |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
Go Back | New Keyword Search