Primal Health Databank: Study

Entry No:0522
Title:The effects of prenatal stress, and of prenatal alcohol and nicotine exposure, on human sexual orientation
Author(s):Ellis L, Cole-Harding S
Reference:Physiol Behav. 2001 Sep 1-15;74(1-2):213-26
Place of Study:USA
Abstract: The present study was undertaken to determine if prenatal stress could be one of the causes of variations in sexual orientation in humans, both singularly and in conjunction with prenatal exposure to alcohol and nicotine. Over 7500 offspring and their mothers provided information regarding the offspring's sexual orientation and the mother's stressful experiences and use of alcohol and nicotine during pregnancy. Findings indicate that prenatal stress has a modest but significant effect on the sexual orientation of male offspring, particularly when the stress occurred during the first trimester of pregnancy. Regarding prenatal exposure to alcohol, no evidence was found to suggest that it impacted offspring sexual orientation of either males or females. Prenatal nicotine exposure, however, appears to significantly increase the probability of lesbianism among female offspring, especially if the exposure occurred in the first trimester along with prenatal stress in the second trimester. The present study is consistent with animal models suggesting that prenatal stress disrupts the typical sex hormonal milieu within which male fetal brains are sexed, thereby feminizing/demasculinizing the male's sexual orientation. However, little support was found for similar effects of prenatal alcohol exposure. In the case of prenatal nicotine, this study is the first to suggest that this drug has masculinizing/defeminizing effects on the sexual orientation of female offspring.
Keyword(s):alcohol in pregnancy, homosexuality, prenatal stress, sexual orientation, smoking
Discussion:No discussion mentioned for this entry
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