Primal Health Databank: Study
| Entry No: | 0495 |
| Title: | Premature Birth and Later Insulin Resistance |
| Author(s): | Hofman P L, Regan F, Jackson WE, Jefferies C, Knight DB, Robinson EM, Wayne S. Cutfield W S |
| Reference: | N England J Med 2004; 351: 2179-86. |
| Place of Study: | New Zealand |
| Abstract: | Seventy-two healthy prepubertal children 4 to 10 years of age were studied: 50 who had been born prematurely (32 weeks' gestation or less), including 38 with a birth weight that was appropriate for gestational age (above the 10th percentile) and 12 with a birth weight that was low (i.e., who were small) for gestational age, and 22 control subjects (at least 37 weeks' gestation, with a birth weight above the 10th percentile). Insulin sensitivity was measured with the use of paired insulin and glucose data obtained by frequent measurements during intravenous glucose-tolerance tests.
Children who had been born prematurely, whether their weight was appropriate or low for gestational age, had an isolated reduction in insulin sensitivity as compared with controls (appropriate-for-gestational-age group, 14.2x10–4 per minute per milliunit per liter [95 percent confidence interval, 11.5 to 16.2]; small-for-gestational-age group, 12.9x10–4 per minute per milliunit per liter [95 percent confidence interval, 9.7 to 17.4]; and control group, 21.6x10–4 per minute per milliunit per liter [95 percent confidence interval, 17.1 to 27.4]; P=0.002). There were no significant differences in insulin sensitivity between the two premature groups (P=0.80). As compared with controls, both groups of premature children had a compensatory increase in acute insulin release (appropriate-for-gestational-age group, 2002 pmol per liter [95 percent confidence interval, 2153 to 2432]; small-for-gestational-age group, 2253 pmol per liter [95 percent confidence interval, 1622 to 3128]; and control group, 1148 pmol per liter [95 percent confidence interval, 875 to 1500]; P<0.001).
Conclusions: Like children who were born at term but who were small for gestational age, children who were born prematurely have an isolated reduction in insulin sensitivity, which may be a risk factor for type 2 diabetes mellitus
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| Keyword(s): | insulin resistance, low birthweight, prematurity |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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