Primal Health Databank: Study
| Entry No: | 0479 |
| Title: | No association between preeclampsia or cesarean section and incidence of type 1 diabetes among children: a large, population-based cohort study |
| Author(s): | Stene LC, Magnus P, Lie RT, Sovik O, Joner G; Norwegian Childhood Diabetes Study Group, Stuver SO, Hsieh C |
| Reference: | Pediatr Res. 2003 Oct;54(4):487-90 |
| Place of Study: | Norway |
| Abstract: | The objective was to investigate whether selected perinatal factors, as indicators of perinatal exposures, are associated with the risk of type 1 diabetes in children. Specifically, the author tested whether maternal preeclampsia, Rhesus-immunization, induced labor, cesarean section, and multiple birth were associated with incidence of type 1 diabetes. A cohort study was designed by linking records of the Medical Birth Registry and the National Childhood Diabetes Registry of Norway. Live births in the study period were followed for a maximum of 15 y and contributed 8,166,731 person-years between 1989 and 1998. Altogether, 1824 cases of type 1 diabetes diagnosed between 1989 and 1998 were identified within the cohort. There was a suggestive, but nonsignificant, increase in risk of type 1 diabetes associated with Rhesus-immunization. Maternal preeclampsia, cesarean section, and the other perinatal factors investigated in this study were not significantly associated with incidence of type 1 diabetes in the children. Previous indications that cesarean section and preeclampsia are associated with type 1 diabetes were not supported by this large study. The majority of routinely recorded perinatal factors are only weakly associated with type 1 diabetes, or not at all. |
| Keyword(s): | caesarean, cesarean, diabetes, diabetes type 1, labor induction, labour induction, pre-eclampsia, preeclampsia, Rhesus-immunization |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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