Primal Health Databank: Study
| Entry No: | 0444 |
| Title: | Fetal exposure to a maternal low protein diet impairs nephrogenesis and promotes hypertension in the rat |
| Author(s): | Langley-Evans SC, Welham SJ, Jackson AA |
| Reference: | Life Sci. 1999;64(11):965-74 |
| Place of Study: | UK |
| Abstract: | Pregnant female rats were fed control (18% casein) or low protein diets throughout pregnancy, or during specific periods. Nephron number was determined at day 20 gestation, full term and 4 weeks of age. Exposure to low protein throughout gestation, or in mid-late gestation increased total nephron number at day 20. By term nephron number was reduced, relative to controls, in rats that were undernourished between days 8-14 or 15-22 gestation. At 4 weeks postnatally rats exposed to low protein throughout fetal life had a reduced (13%) nephron complement and blood pressures 13 mmHg above control animals. Lower renal size and elevated blood pressure persisted to 19 weeks of age, at which time glomerular filtration rate was normal. The data are consistent with the hypothesis that maternal undernutrition may programme the renal nephron number and hence impact upon adult blood pressure and the development of renal disease.
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| Keyword(s): | experimental Primal Health research, nutrition in pregnancy |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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