Primal Health Databank: Study
| Entry No: | 0425 |
| Title: | Supplementary oxygen and risk of childhood lymphatic leukaemia |
| Author(s): | Naumburg E, Bellocco R, Cnattingius S, Jonzon A, Ekbom A |
| Reference: | Acta Paediatr 2002;91(12):1328-33 |
| Place of Study: | Sweden |
| Abstract: | Based on the findings from a previous study a population-based case-control study was performed to investigate the association between childhood leukaemia and exposure to supplementary oxygen and other birth-related factors. Children born in Sweden and diagnosed with lymphatic leukaemia between 1973 and 1989 (578 cases) were individually matched by gender and date of birth to a randomly selected control. Children with Down's syndrome were excluded. Exposure data were blindly gathered from antenatal, obstetric and other standardized medical records. Resuscitation with 100% oxygen with a facemask and bag immediately postpartum was significantly associated with an increased risk of childhood lymphatic leukaemia (OR = 2.57, 95% Cl 1.21-6.82). The oxygen-related risk further increased if the manual ventilation lasted for 3 min or more (OR = 3.54, 95% CI 1.16-10.80). Low Apgar scores at 1 and 5 min were associated with a non-significantly increased risk of lymphatic leukaemia. There were no associations between lymphatic leukaemia and supplementary oxygen later in the neonatal period or other birth-related factors. |
| Keyword(s): | lymphoblastic leukemia, neonatal resuscitation, oxygen, resuscitation |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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