Primal Health Databank: Study
| Entry No: | 0416 |
| Title: | Birthweight, childhood growth and hypertension in adulthood |
| Author(s): | Zhao M, Shu XO, Jin F, Yang G, Li HL, Liu DK, Wen W, Gao YT, Zheng W |
| Reference: | Int J Epidemiol 2002 Oct;31(5):1043-51 |
| Place of Study: | China |
| Abstract: | The authors analysed data among 13 467 women with a recalled birthweight from the Shanghai Women's Health Study. Cases included those with a self-reported hypertension with ('confirmed cases') or without ('possible cases') antihypertensive medication(s) use. Birthweight was inversely associated with the odds of early onset (at age 20-40 years) hypertension in a dose response manner. This association is stronger for 'confirmed' hypertension (only odds ratio for 'confirmed' hypertension are referred to subsequently). Being heavier or taller than average at 15 years of age were both related to elevated odds of early onset hypertension. Women who had a low birthweight but were heavier than average at age 15 were more than four times (OR = 4.63, 95% CI: 2.40-8.94) more likely to have an early onset hypertension, and those who had a low BW and became taller at 15 years of age had an OR of 1.87 (95% CI: 1.05-3.31). A significant interaction between birthweight and weight at age 15 was observed (P = 0.04). This study suggests that low birthweight, particularly if accompanied by accelerated childhood growth, may increase the risk of early onset hypertension in adulthood.
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| Keyword(s): | birthweight, Blood pressure, height, hypertension |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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