Primal Health Databank: Study
| Entry No: | 0407 |
| Title: | Inverse association between melanoma and previous vaccinations against tuberculosis and smallpox: results of the FEBIM study |
| Author(s): | Pfahlberg A, Kolmel KF, Grange JM, Mastrangelo G, Krone B, Botev IN, Niin M, Seebacher C, Lambert D, Shafir R, Schneider D, Kokoschka EM, Kleeberg UR, Uter W, Gefeller O |
| Reference: | J Invest Dermatol 2002 Sep;119(3):570-5 |
| Place of Study: | Germany |
| Abstract: | Various forms of immunotherapy utilizing bacille Calmette-Guerin vaccine or vaccinia vaccine have been evaluated in clinical trials on melanoma patients. The effect of the "natural" application of these vaccinations, administered to provide protection against tuberculosis and smallpox, has, however, never been studied in epidemiologic investigations on risk factors for melanoma. In a case-control study comprising 11 institutions in seven countries the authors recruited 603 incident melanoma cases and 627 population controls frequency matched to the cases with respect to sex, age, and ethnic origin within each center to assess this relationship to obtain insights into the prevention of melanoma. Exposure information, incorporating also detailed ascertainment of potential confounding variables, was obtained in standardized personal interviews at the study subject's home. The authors found an inverse association between melanoma risk and previous bacille Calmette-Guerin vaccine/vaccinia vaccination depicted by an adjusted odds ratio of 0.44 (95% confidence interval: 0.26-0.72) for those vaccinated against tuberculosis and smallpox compared with subjects without a positive history of either vaccination. A variety of subgroup analyses showing a consistent pattern of results make it unlikely that the observed inverse association is a spurious finding. The authors conclude that bacille Calmette-Guerin vaccination and vaccinia vaccination may lower melanoma risk. Current immunologic theory of melanoma development provides a sound basis for understanding the biologic plausibility of the findings that have to be confirmed in future studies |
| Keyword(s): | BCG, melanoma, vaccination |
| Discussion: | Since most subjects were vaccinated during their 'Primal period', this study may be included in the Primal Health Research data bank |
| See Also: | No related entries mentioned for this entry |
Go Back | New Keyword Search