Primal Health Databank: Study
| Entry No: | 0376 |
| Title: | Association of a Woman's Own Birth Weight With Subsequent Risk for Gestational Diabetes |
| Author(s): | Innes KE, Byers TE, Marshall JA, et al. |
| Reference: | JAMA. 2002;287:2534-2541 |
| Place of Study: | USA |
| Abstract: | The objective of this study was to test the hypothesis that a woman's own fetal growth is inversely related to her later risk for gestational diabetes.
Healthy women who completed their first pregnancies in New York State between 1994 and 1998 and who were also born in New York State participated in the study. Records from each woman's first pregnancy were linked to those from her own birth (1970-1985). Cases were 440 women with a record of gestational diabetes. Controls were 22 955 remaining women with no indication of gestational diabetes.
Birth weight showed a U-shaped relationship to a woman's risk of gestational diabetes in her first pregnancy, with the highest risks associated with low and high birth weights. Odds ratios (ORs) adjusted for gestational age were 2.16 (95% confidence interval [CI], 1.04-4.50) for birth weight of less than 2000 g and 1.53 (95% CI, 1.03-2.27) for a birth weight of 4000 g or more. Adjustment for potential confounding factors, particularly prepregnancy body mass index and maternal diabetes, increased the OR for low birth weight to 4.23 (95% CI, 1.55-11.51), but reduced the OR for high birth weight to 0.92 (95% CI, 0.54-1.57), leaving a strong inverse dose-response relationship between birth weight and risk of gestational diabetes (adjusted P for trend <.001).
In this large population-based study,it appears that a woman's own birth weight is strongly and inversely related to her risk of gestational diabetes, suggesting that intrauterine environment may be important.
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| Keyword(s): | birthweight, gestational diabetes |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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