Primal Health Databank: Study
| Entry No: | 0358 |
| Title: | Intrauterine Exposure to Diagnostic X Rays and Risk of Childhood Leukemia Subtypes |
| Author(s): | Naumburg E, Bellocco R, Cnattingius S, Hall P, Boice JD, Ekbom A |
| Reference: | Radiat Res 2001 Dec;156(6):718-723 |
| Place of Study: | Sweden |
| Abstract: | This population-based case-control study investigated the association between prenatal exposure to diagnostic X-ray examinations (for different types of examinations and at different stages of pregnancy) and the risk of childhood lymphatic and myeloid leukemia. All children born and diagnosed with leukemia between 1973-1989 in Sweden (578 lymphatic and 74 myeloid) were selected as cases, and each was matched (by sex and year of birth) to a healthy control child (excluding Down's syndrome). Exposure data were abstracted blindly from all available medical records. It was found that prenatal X-ray examinations resulting in direct fetal exposure were not associated with a significant overall increased risk for childhood leukemia (OR = 1.11, 95% CI 0.83-1.47), for lymphatic leukemia (OR = 1.04, 95% CI 0.77-1.40), or for myeloid leukemia (OR = 1.49, 95% CI 0.48-4.72). There was little evidence of a dose response or variation in risk by trimester of exposure or age at diagnosis. Thus X-ray examinations performed during pregnancy in the 1970s and 1980s in Sweden did not affect the risk of childhood leukemia discernibly |
| Keyword(s): | cancer in childhood, diagnostic X Rays, leukemia |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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