Primal Health Databank: Study
| Entry No: | 0322 |
| Title: | Relation of infant feeding to adult serum cholesterol concentration and death |
| Author(s): | Fall CHD. Barker DJP. Osmond C, et al. |
| Reference: | BMJ. Vol 304(6830) (pp 801-805), 1992 |
| Place of Study: | UK |
| Abstract: | This is a follow up study of men born during 1911-30 in Hertforshire, England. The subjects were 5718 men, for 5471 of whom information on infant feeding had been recorded by health visitors and 1314 of whom had died. 485 of the men born during 1920-30 were still living in Hertfordshire and had blood lipid measurements. The main outcome measures were death from ischaemic heart disease and serum cholesterol and apolipoprotein concentrations. 474 men had died from ischaemic heart disease. Mortality ratios were 97 (95% confidence interval 81 to 115) in men who had been breast fed and had not been weaned at 1 year, 79 (69 to 90) in breast fed men who had been weaned at 1 year, and 73 (59 to 89) in men who had been breast and bottle fed. Compared with men weaned before one year men not wean had higher mean serum concentrations of total cholesterol and apolipoprotein B. Men who had been bottle fed also had a high standardised mortality ratio for ischaemic heart disease (95; 68 to 130) and high mean serum concentrations of total cholesterol, low density lipoprotein cholesterol, and apolipoprotein B. In all feeding groups serum apolipoprotein B concentrations were lower in men with higher birth weight and weight at 1 year. This study suggests that men born earlier this century who had still been breastfed aged 1 year had higher rates of coronary heart disease 60-70 years later compared with the expected rate for men of that age. |
| Keyword(s): | apolipoprotein, bottle feeding, breastfeeding, cholesterol, coronary heart disease |
| Discussion: | One of the studies suggesting that prolonged breastfeeding might increase the risks of coronary heart disease. |
| See Also: | No related entries mentioned for this entry |
Go Back | New Keyword Search