Primal Health Databank: Study
| Entry No: | 0309 |
| Title: | Atopy, lung function, and obstructive airways disease after prenatal exposure to famine |
| Author(s): | Lopuhaa CE, Roseboom TJ, Osmond C, et al. |
| Reference: | Thorax 2000; 55 (7): 555-61 |
| Place of Study: | Netherlands |
| Abstract: | Nine hundred and twelve people aged about 50, born at term between November 1943 and February 1947 in Amsterdam, were asked about their medical history. Lung function was measured in 733 and serum concentrations of total IgE and specific IgE against mite, pollen and cat were measured in 726. Those exposed in late, mid, and early gestation (exposed participants) were compared with those born before or conceived after the famine (non-exposed participants). Exposure to famine during gestation affected neither the concentrations of total or specific IgE nor lung function values. The prevalence of obstructive airways disease was increased in people exposed to famine in mid gestation and tended to be higher in those exposed in early gestation. The observed increase in the prevalence of obstructive airways disease in people exposed to famine in mid and early gestation was not parallelled by effects on IgE concentrations or lung function. The link between exposure to famine in mid and early gestation and obstructive airways disease in adulthood suggests that fetal lungs can be permanently affected by nutritional challenges during periods of rapid growth. |
| Keyword(s): | asthma, atopy, famine, fetal life, lung function |
| Discussion: | No discussion mentioned for this entry |
| See Also: | No related entries mentioned for this entry |
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