Primal Health Databank: Study
| Entry No: | 0260 |
| Title: | Prenatal and perinatal risk factors for schizophrenia, affective psychosis and reactive psychosis of early onset: case-control study |
| Author(s): | Hultman CM, Sparen P, et al. |
| Reference: | BMJ 1999; 318: 121-6 |
| Place of Study: | Sweden |
| Abstract: | All Swedish children born during 1973-79 were involved in the study. Data from the Swedish birth register were linked with data from the Swedish inpatient register. The registers provide nationwide coverage for the study. Schizophrenia was positively associated with multiparity (odds ratio 2.0), maternal bleeding during pregnancy (odds ratio 3.5) and birth in late winter (odds ratio 1.4). Affective psychosis was associated with uterine atony (odds ratio 2.2) and late winter birth (odds ratio 1.5). Reactive psychosis was related to multiparity (odds ratio 2.1). An increased risk for schizophrenia was found in boys who were small for their gestational age at birth (odds ratio 3.2), who were number four or more in birth order (odds ratio 3.6) and whose mothers had had bleeding during late pregnancy (odds ratio 4.0). |
| Keyword(s): | birth order, birth weight, bleeding during pregnancy, psychosis, schizophrenia, seasonality of birth, small for gestational age infants |
| Discussion: | One of the most convincing studies suggesting that the chain of events leading to schizophrenia starts during fetal life. |
| See Also: | No related entries mentioned for this entry |
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