Primal Health Databank: Study
| Entry No: | 0203 |
| Title: | A randomised double blind controlled trial of the value of stilbestrol therapy in pregnancy: long-term follow-up of mothers and their offspring. |
| Author(s): | Vessey MP, Fairweather DVI, et al. |
| Reference: | Brit J Obstet and Gynaec 1983; 90: 1007-1017 |
| Place of Study: | London, England |
| Abstract: | In the early 1950's, a randomised double-blind controlled trial of the value of stilbestrol given during pregnancy to improve the perinatal outcomes was conducted at University College Hospital, London. Women expecting their first baby were allocated to one or other of two groups. Long-term follow-up data from 650 mothers and 660 offspring could be obtained. The authors found no indication of any harmful long-term effect of stilbestrol therapy on the mothers (10 out of 331 women in the untreated group and 9 out of 319 were found to have developed breast cancer). Among the daughters those in the treated group suffered an excess of minor benign lesions of the cervix and an excess (not statistically significant) of unfavourable pregnancy outcomes. None of the daughters in this series had developed a cancer of the vagina. Among the sons there was no evidence of any significant excess of genital tract disorders of impaired reproductive performance in the treated group, but one son developed a fatal teratoma of the testis. Depression and anxiety were reported twice more often in the treated group offspring. This was not statistically significant. |
| Keyword(s): | anxiety levels, cancer, depression, stilbestrol |
| Discussion: | This is one of the long-term follow-up studies of mothers and their offspring after stilbestrol therapy given antenatally. See entry 0202. |
| See Also: | 0202 |
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