Primal Health Databank: Study
| Entry No: | 0140 |
| Title: | Population based study of long-term outcomes after amniocentesis |
| Author(s): | Baird PA, Yee IML, Sadovnick AD |
| Reference: | Lancet 1994; 344: 1134-36 |
| Place of Study: | British Columbia, Canada |
| Abstract: | This is the largest study of long term adverse effects on children of amniocentesis with one of the longest periods of follow-up (7-18 years). Consecutive live-born offspring of women who have had amniocentesis were compared with matched controls whose mother had not had amniocentesis. The controls were matched for age of mother, residence, sex, and when the birth occurred. 1296 cases and 3704 controls were studied. The offspring of women who had had amniocentesis were no more likely than controls to have a registerable disability (such as hearing disability, learning difficulty, visual problem, limb anomalies) during childhood and adolescence. The follow up period was 7-18 years. The only significant difference between both groups was the higher rate of haemolytic disease due to ABO iso-immunisation in cases. Let's mention that the potential for iso-immunisation during amniocentesis had already been recognised previously with respect to rhesus compatibility. |
| Keyword(s): | amniocentesis, haemolytic disease, hearing disability, learning difficulties, limb anomalies, vision |
| Discussion: | Such findings confirm those of smaller studies (see entries 0141 to 0145) |
| See Also: | 0141, 0142, 0143, 0144, 0145 |
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