Primal Health Databank: Study
| Entry No: | 0107 |
| Title: | Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study |
| Author(s): | Stanner SA, Bulmer K, et al. |
| Reference: | BMJ 1997; 315: 1342-9 |
| Place of Study: | Leningrad, Russia |
| Abstract: | The objective was to investigate the relation between decreased maternal food intake and risk factors for coronary heart disease in adult life. 169 subjects exposed to malnutrition in utero during the siege of Leningrad were compared with 192 subjects born in Leningrad just before the siege, and with 188 subjects born at the same time outside the area of the siege. Intrauterine malnutrition was not associated with glucose intolerance, dyslipidaemia, hypertension, or cardiovascular disease in adulthood. Subjects exposed to malnutrition showed evidence of endothelial dysfunction (raised von Willebrand factor) and a stronger influence of obesity on blood pressure. |
| Keyword(s): | coronary heart disease, famine, obesity, starvation |
| Discussion: | The interest of such a study is that a correlation was established between the risk of adult diseases and starvation in fetal life. The correlation was not explored in regard to birth weight. See also entry 0106, 0127 and 0219. |
| See Also: | 0106, 0127, 0219 |
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